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First, phase II clinical trials evaluating MOTS-c in type 2 diabetes and sarcopenia are in development, and their results will provide the first randomized controlled evidence in humans to define therapeutic doses with statistical rigor
doi:10.1111/j.1365-313X.2007.03280.x
Reduction of triglyceride levels and very-low-density cholesterol were greatest with the 2.4 and 4.5 mg doses of cagrilintide, while changes from baseline of the other lipid and cholesterol levels were relatively similar across treatment groups [1]
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Standard metabolic labs (HbA1c, lipid panel, liver enzymes, renal function) are far more relevant for assessing tirzepatide candidacy and monitoring treatment response
